Publikationen des gesamten Lehrstuhls (Auszug)

  • 2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors. Lohse, M. J.; Klotz, K. N.; Diekmann, E.; Friedrich, K.; Schwabe, U. in Eur J Pharmacol (1988). 156(1) 157-60.
     
  • 2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors. Volpini, R.; Costanzi, S.; Lambertucci, C.; Vittori, S.; Martini, C.; Trincavelli, M. L.; Klotz, K. N.; Cristalli, G. in Purinergic Signal (2005). 1(2) 173-81.
     
  • 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching. Novellino, E.; Cosimelli, B.; Ehlardo, M.; Greco, G.; Iadanza, M.; Lavecchia, A.; Rimoli, M. G.; Sala, A.; Settimo, A. Da; Primofiore, G.; Settimo, F. Da; Taliani, S.; Motta, C. La; Klotz, K. N.; Tuscano, D.; Trincavelli, M. L.; Martini, C. in J Med Chem (2005). 48(26) 8253-60.
     
  • 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Lohse, M. J.; Klotz, K. N.; Schwabe, U.; Cristalli, G.; Vittori, S.; Grifantini, M. in Naunyn Schmiedebergs Arch Pharmacol (1988). 337(6) 687-9.
     
  • 2-substituted 5'-N-methylcarboxamidoadenosine (MECA) derivatives as A3 adenosine receptor ligands. Vittori, S.; Volpini, R.; Lambertucci, C.; Taffi, S.; Klotz, K. N.; Cristalli, G. in Nucleosides Nucleotides Nucleic Acids (2005). 24(5-7) 935-8.
     
  • 7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors. Macchia, M.; Salvetti, F.; Bertini, S.; Bussolo, V. Di; Gattuso, L.; Gesi, M.; Hamdan, M.; Klotz, K. N.; Laragione, T.; Lucacchini, A.; Minutolo, F.; Nencetti, S.; Papi, C.; Tuscano, D.; Martini, C. in Bioorg Med Chem Lett (2001). 11(23) 3023-6.
     
  • 8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists. Muller, C. E.; Sandoval-Ramirez, J.; Schobert, U.; Geis, U.; Frobenius, W.; Klotz, K. N. in Bioorg Med Chem (1998). 6(6) 707-19.
     
  • 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors. Lohse, M. J.; Klotz, K. N.; Lindenborn-Fotinos, J.; Reddington, M.; Schwabe, U.; Olsson, R. A. in Naunyn Schmiedebergs Arch Pharmacol (1987). 336(2) 204-10.
     
  • [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Varani, K.; Merighi, S.; Gessi, S.; Klotz, K. N.; Leung, E.; Baraldi, P. G.; Cacciari, B.; Romagnoli, R.; Spalluto, G.; Borea, P. A. in Mol Pharmacol (2000). 57(5) 968-75.
     
  • [3H]-8-cyclopentyl-1,3-dipropylxanthine binding to A1 adenosine receptors of intact rat ventricular myocytes. Martens, D.; Lohse, M. J.; Schwabe, U. in Circ Res (1988). 63(3) 613-20.
     
  • [Effect of allopurinol on adrenergically induced changes in serum lipid levels, heart rate and blood pressure in normal and ischemic rabbits (author's transl)]. Sziegoleit, W.; Lohse, M.; Riedel, H.; Forster, W. in Arzneimittelforschung (1982). 32(3) 218-21.
     
  • [Effect of allopurinol on the liberation of free fatty acids from isolated rat and rabbit adipose tissue, stimulated by noradrenaline or adrenocortico-tropic hormone]. Sziegoleit, W.; Schmidt, C.; Lohse, M.; Forster, W. in Acta Biol Med Ger (1981). 40(6) 881-3.
     
  • [Value of intra-anal ultrasound study for structural analysis of the continence organ--initial results]. Schaarschmidt, K.; Willital, G. H.; Bunemann, M.; Jung, K. in Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir (1989). 1007-12.
     
  • A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. Pei, G.; Samama, P.; Lohse, M.; Wang, M.; Codina, J.; Lefkowitz, R. J. in Proc Natl Acad Sci U S A (1994). 91(7) 2699-702.
     
  • A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. Maier-Peuschel, M.; Frolich, N.; Dees, C.; Hommers, L. G.; Hoffmann, C.; Nikolaev, V. O.; Lohse, M. J. in J Biol Chem (2010). 285(12) 8793-800.
     
  • A guide to using MapMan to visualize and compare Omics data in plants: a case study in the crop species, Maize. Usadel, B.; Poree, F.; Nagel, A.; Lohse, M.; Czedik-Eysenberg, A.; Stitt, M. in Plant Cell Environ (2009). 32(9) 1211-29.
     
  • A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists. Yan, L.; Bertarelli, D. C.; Hayallah, A. M.; Meyer, H.; Klotz, K. N.; Muller, C. E. in J Med Chem (2006). 49(14) 4384-91.
     
  • A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Lorenz, K.; Schmitt, J. P.; Schmitteckert, E. M.; Lohse, M. J. in Nat Med (2009). 15(1) 75-83.
     
  • A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure. Nikolaev, V. O.; Boivin, V.; Stork, S.; Angermann, C. E.; Ertl, G.; Lohse, M. J.; Jahns, R. in J Am Coll Cardiol (2007). 50(5) 423-31.
     
  • A role for caspase-1 in heart failure. Merkle, S.; Frantz, S.; Schon, M. P.; Bauersachs, J.; Buitrago, M.; Frost, R. J.; Schmitteckert, E. M.; Lohse, M. J.; Engelhardt, S. in Circ Res (2007). 100(5) 645-53.
     
  • A2B adenosine receptor agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl adenosine and NECA derivatives. Vittori, S.; Costanzi, S.; Lambertucci, C.; Portino, F. R.; Taffi, S.; Volpini, R.; Klotz, K. N.; Cristalli, G. in Nucleosides Nucleotides Nucleic Acids (2004). 23(1-2) 471-81.
     
  • Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Paris, A.; Philipp, M.; Tonner, P. H.; Steinfath, M.; Lohse, M.; Scholz, J.; Hein, L. in Anesthesiology (2003). 99(4) 889-95.
     
  • Activation of AP-1 contributes to the beta-adrenoceptor-mediated myocardial induction of interleukin-6. Rohrbach, S.; Engelhardt, S.; Lohse, M. J.; Werdan, K.; Holtz, J.; Muller-Werdan, U. in Mol Med (2007). 13(11-12) 605-14.
     
  • Activation of beta-adrenergic receptor kinase during myocardial ischemia. Ungerer, M.; Kessebohm, K.; Kronsbein, K.; Lohse, M. J.; Richardt, G. in Circ Res (1996). 79(3) 455-60.
     
  • Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats. Ungerer, M.; Obermaier-Skrobranek, B.; Lohse, M. J. in Eur J Pharmacol (1992). 226(4) 381-2.
     
  • Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Volpini, R.; Ben, D. Dal; Lambertucci, C.; Marucci, G.; Mishra, R. C.; Ramadori, A. T.; Klotz, K. N.; Trincavelli, M. L.; Martini, C.; Cristalli, G. in ChemMedChem (2009). 4(6) 1010-9.
     
  • Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells. Merighi, S.; Mirandola, P.; Milani, D.; Varani, K.; Gessi, S.; Klotz, K. N.; Leung, E.; Baraldi, P. G.; Borea, P. A. in J Invest Dermatol (2002). 119(4) 923-33.
     
  • Adenosine receptors on heart muscle. Lohse, M. J.; Ukena, D.; Schwabe, U. in Lancet (1984). 2(8398) 355.
     
  • Adenosine regulates the Ca2+ sensitivity of mast cell mediator release. Lohse, M. J.; Klotz, K. N.; Salzer, M. J.; Schwabe, U. in Proc Natl Acad Sci U S A (1988). 85(23) 8875-9.
     
  • Agonist photoaffinity labeling of A1 adenosine receptors: persistent activation reveals spare receptors. Lohse, M. J.; Klotz, K. N.; Schwabe, U. in Mol Pharmacol (1986). 30(4) 403-9.
     
  • Agonist-dependent delivery of M(2) muscarinic acetylcholine receptors to the cell surface after pertussis toxin treatment. Roseberry, A. G.; Bunemann, M.; Elavunkal, J.; Hosey, M. M. in Mol Pharmacol (2001). 59(5) 1256-68.
     
  • Agonist-induced internalization and recycling of the human A(3) adenosine receptors: role in receptor desensitization and resensitization. Trincavelli, M. L.; Tuscano, D.; Cecchetti, P.; Falleni, A.; Benzi, L.; Klotz, K. N.; Gremigni, V.; Cattabeni, F.; Lucacchini, A.; Martini, C. in J Neurochem (2000). 75(4) 1493-501.
     
  • Alpha-1 adrenoceptor-mediated positive inotropic effect and inositol trisphosphate increase in mammalian heart. Scholz, J.; Schaefer, B.; Schmitz, W.; Scholz, H.; Steinfath, M.; Lohse, M.; Schwabe, U.; Puurunen, J. in J Pharmacol Exp Ther (1988). 245(1) 327-35.
     
  • Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice. Spindler, M.; Engelhardt, S.; Niebler, R.; Wagner, H.; Hein, L.; Lohse, M. J.; Neubauer, S. in J Mol Cell Cardiol (2003). 35(4) 389-97.
     
  • Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Schmitt, J. P.; Ahmad, F.; Lorenz, K.; Hein, L.; Schulz, S.; Asahi, M.; Maclennan, D. H.; Seidman, C. E.; Seidman, J. G.; Lohse, M. J. in Circulation (2009). 119(3) 436-44.
     
  • Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Ungerer, M.; Bohm, M.; Elce, J. S.; Erdmann, E.; Lohse, M. J. in Circulation (1993). 87(2) 454-63.
     
  • Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures. Lotz, M.; Ebert, S.; Esselmann, H.; Iliev, A. I.; Prinz, M.; Wiazewicz, N.; Wiltfang, J.; Gerber, J.; Nau, R. in J Neurochem (2005). 94(2) 289-98.
     
  • An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro. Mayer, G.; Wulffen, B.; Huber, C.; Brockmann, J.; Flicke, B.; Neumann, L.; Hafenbradl, D.; Klebl, B. M.; Lohse, M. J.; Krasel, C.; Blind, M. in RNA (2008). 14(3) 524-34.
     
  • Autoradiographic visualization of A1 adenosine receptors in rat brain with [3H]8-cyclopentyl-1,3-dipropylxanthine. Weber, R. G.; Jones, C. R.; Lohse, M. J.; Palacios, J. M. in J Neurochem (1990). 54(4) 1344-53.
     
  • Autoradiographic visualization of A1-adenosine receptors in brain and peripheral tissues of rat and guinea pig using 125I-HPIA. Weber, R. G.; Jones, C. R.; Palacios, J. M.; Lohse, M. J. in Neurosci Lett (1988). 87(3) 215-20.
     
  • Barbiturates are selective antagonists at A1 adenosine receptors. Lohse, M. J.; Klotz, K. N.; Jakobs, K. H.; Schwabe, U. in J Neurochem (1985). 45(6) 1761-70.
     
  • beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites. Reiner, S.; Ziegler, N.; Leon, C.; Lorenz, K.; von Hayn, K.; Gachet, C.; Lohse, M. J.; Hoffmann, C. in Mol Pharmacol (2009). 76(6) 1162-71.
     
  • Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Nikolaev, V. O.; Moshkov, A.; Lyon, A. R.; Miragoli, M.; Novak, P.; Paur, H.; Lohse, M. J.; Korchev, Y. E.; Harding, S. E.; Gorelik, J. in Science (2010). 327(5973) 1653-7.
     
  • Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling. Slupsky, J. R.; Quitterer, U.; Weber, C. K.; Gierschik, P.; Lohse, M. J.; Rapp, U. R. in Curr Biol (1999). 9(17) 971-4.
     
  • Binding of purified recombinant beta-arrestin to guanine-nucleotide-binding-protein-coupled receptors. Sohlemann, P.; Hekman, M.; Puzicha, M.; Buchen, C.; Lohse, M. J. in Eur J Biochem (1995). 232(2) 464-72.
     
  • Binding thermodynamics at the human A(3) adenosine receptor. Merighi, S.; Varani, K.; Gessi, S.; Klotz, K. N.; Leung, E.; Baraldi, P. G.; Borea, P. A. in Biochem Pharmacol (2002). 63(2) 157-61.
     
  • Blocking them all: beta-arrestins inhibit cellular signaling. Lohse, M. J.; Klenk, C. in Mol Cell (2008). 31(5) 619-21.
     
  • Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide. Stagi, M.; Dittrich, P. S.; Frank, N.; Iliev, A. I.; Schwille, P.; Neumann, H. in J Neurosci (2005). 25(2) 352-62.
     
  • Ca2+ cycling and new therapeutic approaches for heart failure. Lompre, A. M.; Hajjar, R. J.; Harding, S. E.; Kranias, E. G.; Lohse, M. J.; Marks, A. R. in Circulation (2010). 121(6) 822-30.
     
  • cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes. Warrier, S.; Ramamurthy, G.; Eckert, R. L.; Nikolaev, V. O.; Lohse, M. J.; Harvey, R. D. in J Physiol (2007). 580(Pt.3) 765-76.
     
  • Carbamazepine distinguishes between adenosine receptors that mediate different second messenger responses. Calker, D. Van; Steber, R.; Klotz, K. N.; Greil, W. in Eur J Pharmacol (1991). 206(4) 285-90.
     
  • Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling. Lorenz, K.; Schmitt, J. P.; Vidal, M.; Lohse, M. J. in Int J Biochem Cell Biol (2009). 41(12) 2351-5.
     
  • Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Schmitt, J. P.; Debold, E. P.; Ahmad, F.; Armstrong, A.; Frederico, A.; Conner, D. A.; Mende, U.; Lohse, M. J.; Warshaw, D.; Seidman, C. E.; Seidman, J. G. in Proc Natl Acad Sci U S A (2006). 103(39) 14525-30.
     
  • Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-myc) represent independent loci as determined by their chromosomal map location in the rat. Tsichlis, P. N.; Lohse, M. A.; Szpirer, C.; Szpirer, J.; Levan, G. in J Virol (1985). 56(3) 938-42.
     
  • Changes of creatine kinase gene expression in rat heart post-myocardial infarction. Neubauer, S.; Frank, M.; Hu, K.; Remkes, H.; Laser, A.; Horn, M.; Ertl, G.; Lohse, M. J. in J Mol Cell Cardiol (1998). 30(4) 803-10.
     
  • Characterization of [3H]phenobarbital binding to rat brain membranes. Lohse, M. J.; Klotz, K. N.; Ukena, D.; Schwabe, U. in Neurosci Lett (1984). 52(1-2) 97-101.
     
  • Characterization of adenosine A1 receptor in a cell line (28A) derived from rabbit collecting tubule. Spielman, W. S.; Klotz, K. N.; Arend, L. J.; Olson, B. A.; LeVier, D. G.; Schwabe, U. in Am J Physiol (1992). 263(2 Pt 1) C502-8.
     
  • Characterization of the K(+)-channel-coupled adenosine receptor in guinea pig atria. Tawfik-Schlieper, H.; Klotz, K. N.; Kreye, V. A.; Schwabe, U. in Naunyn Schmiedebergs Arch Pharmacol (1989). 340(6) 684-8.
     
  • Circadian and short-term regulation of blood pressure and heart rate in transgenic mice with cardiac overexpression of the beta1-adrenoceptor. Witte, K.; Engelhardt, S.; Janssen, B. J.; Lohse, M.; Lemmer, B. in Chronobiol Int (2004). 21(2) 205-16.
     
  • Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites. Michielan, L.; Bolcato, C.; Federico, S.; Cacciari, B.; Bacilieri, M.; Klotz, K. N.; Kachler, S.; Pastorin, G.; Cardin, R.; Sperduti, A.; Spalluto, G.; Moro, S. in Bioorg Med Chem (2009). 17(14) 5259-74.
     
  • Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Roth, N. S.; Campbell, P. T.; Caron, M. G.; Lefkowitz, R. J.; Lohse, M. J. in Proc Natl Acad Sci U S A (1991). 88(14) 6201-4.
     
  • Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis. Tsichlis, P. N.; Strauss, P. G.; Lohse, M. A. in J Virol (1985). 56(1) 258-67.
     
  • Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Vilardaga, J. P.; Nikolaev, V. O.; Lorenz, K.; Ferrandon, S.; Zhuang, Z.; Lohse, M. J. in Nat Chem Biol (2008). 4(2) 126-31.
     
  • Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy. Schmitt, J. P.; Semsarian, C.; Arad, M.; Gannon, J.; Ahmad, F.; Duffy, C.; Lee, R. T.; Seidman, C. E.; Seidman, J. G. in Circulation (2003). 108(9) 1133-8.
     
  • Constitutively active germline mutation of the thyrotropin receptor gene as a cause of congenital hyperthyroidism. Schwab, K. O.; Gerlich, M.; Broecker, M.; Sohlemann, P.; Derwahl, M.; Lohse, M. J. in J Pediatr (1997). 131(6) 899-904.
     
  • Crosstalk between Galpha(i)- and Galpha(q)-coupled receptors is mediated by Gbetagamma exchange. Quitterer, U.; Lohse, M. J. in Proc Natl Acad Sci U S A (1999). 96(19) 10626-31.
     
  • Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Nikolaev, V. O.; Bunemann, M.; Schmitteckert, E.; Lohse, M. J.; Engelhardt, S. in Circ Res (2006). 99(10) 1084-91.
     
  • Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Norris, R. P.; Ratzan, W. J.; Freudzon, M.; Mehlmann, L. M.; Krall, J.; Movsesian, M. A.; Wang, H.; Ke, H.; Nikolaev, V. O.; Jaffe, L. A. in Development (2009). 136(11) 1869-78.
     
  • Demonstration of Ri-type adenosine receptors in bovine myocardium by radioligand binding. Lohse, M. J.; Ukena, D.; Schwabe, U. in Naunyn Schmiedebergs Arch Pharmacol (1985). 328(3) 310-6.
     
  • Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Pitcher, J.; Lohse, M. J.; Codina, J.; Caron, M. G.; Lefkowitz, R. J. in Biochemistry (1992). 31(12) 3193-7.
     
  • Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. Vilardaga, J. P.; Frank, M.; Krasel, C.; Dees, C.; Nissenson, R. A.; Lohse, M. J. in J Biol Chem (2001). 276(36) 33435-43.
     
  • Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium. Palmer, B. M.; Fishbaugher, D. E.; Schmitt, J. P.; Wang, Y.; Alpert, N. R.; Seidman, C. E.; Seidman, J. G.; VanBuren, P.; Maughan, D. W. in Am J Physiol Heart Circ Physiol (2004). 287(1) H91-9.
     
  • Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. Reiner, S.; Ambrosio, M.; Hoffmann, C.; Lohse, M. J. in J Biol Chem (2010).
     
  • Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Schmitt, J. P.; Kamisago, M.; Asahi, M.; Li, G. H.; Ahmad, F.; Mende, U.; Kranias, E. G.; MacLennan, D. H.; Seidman, J. G.; Seidman, C. E. in Science (2003). 299(5611) 1410-3.
     
  • Direct optical recording of intrinsic efficacy at a G protein-coupled receptor. Lohse, M. J.; Vilardaga, J. P.; Bunemann, M. in Life Sci (2003). 74(2-3) 397-404.
     
  • Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. Wachten, S.; Masada, N.; Ayling, L. J.; Ciruela, A.; Nikolaev, V. O.; Lohse, M. J.; Cooper, D. M. in J Cell Sci (2010). 123(Pt 1) 95-106.
     
  • Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts. Wiesmann, F.; Ruff, J.; Engelhardt, S.; Hein, L.; Dienesch, C.; Leupold, A.; Illinger, R.; Frydrychowicz, A.; Hiller, K. H.; Rommel, E.; Haase, A.; Lohse, M. J.; Neubauer, S. in Circ Res (2001). 88(6) 563-9.
     
  • Dual actions of adenosine on rat peritoneal mast cells. Lohse, M. J.; Maurer, K.; Gensheimer, H. P.; Schwabe, U. in Naunyn Schmiedebergs Arch Pharmacol (1987). 335(5) 555-60.
     
  • Effects of adenosine on histamine release from human lung fragments. Ott, I.; Lohse, M. J.; Klotz, K. N.; Vogt-Moykopf, I.; Schwabe, U. in Int Arch Allergy Immunol (1992). 98(1) 50-6.
     
  • Effects of temperature and membrane phase transitions on ligand binding to alpha 2-receptors of human platelets. Lohse, M. J.; Klotz, K. N.; Schwabe, U. in Mol Pharmacol (1986). 29(3) 228-34.
     
  • Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. Offermanns, S.; Zhao, L. P.; Gohla, A.; Sarosi, I.; Simon, M. I.; Wilkie, T. M. in EMBO J (1998). 17(15) 4304-12.
     
  • Evidence for an A2 adenosine receptor in guinea pig lung. Ukena, D.; Schirren, C. G.; Klotz, K. N.; Schwabe, U. in Naunyn Schmiedebergs Arch Pharmacol (1985). 331(1) 89-95.
     
  • Evolution of melanocortin receptors in teleost fish: the melanocortin type 1 receptor. Selz, Y.; Braasch, I.; Hoffmann, C.; Schmidt, C.; Schultheis, C.; Schartl, M.; Volff, J. N. in Gene (2007). 401(1-2) 114-22.
     
  • Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic. Oey, M.; Lohse, M.; Kreikemeyer, B.; Bock, R. in Plant J (2009). 57(3) 436-45.
     
  • Exploring potency and selectivity receptor antagonist profiles using a multilabel classification approach: the human adenosine receptors as a key study. Michielan, L.; Stephanie, F.; Terfloth, L.; Hristozov, D.; Cacciari, B.; Klotz, K. N.; Spalluto, G.; Gasteiger, J.; Moro, S. in J Chem Inf Model (2009). 49(12) 2820-36.
     
  • Expression of beta 2-adrenoceptors in halobacteria. Sohlemann, P.; Soppa, J.; Oesterhelt, D.; Lohse, M. J. in Naunyn Schmiedebergs Arch Pharmacol (1997). 355(2) 150-60.
     
  • Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. Ungerer, M.; Parruti, G.; Bohm, M.; Puzicha, M.; DeBlasi, A.; Erdmann, E.; Lohse, M. J. in Circ Res (1994). 74(2) 206-13.
     
  • Expression of phosducin in a phosducin-negative cell line reveals functions of a Gbetagamma-binding protein. Schulz, K.; Danner, S.; Bauer, P.; Schroder, S.; Lohse, M. J. in J Biol Chem (1996). 271(37) 22546-51.
     
  • Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system. Pohler, D.; Butt, E.; Meissner, J.; Muller, S.; Lohse, M.; Walter, U.; Lohmann, S. M.; Jarchau, T. in FEBS Lett (1995). 374(3) 419-25.
     
  • Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes. Zurn, A.; Zabel, U.; Vilardaga, J. P.; Schindelin, H.; Lohse, M. J.; Hoffmann, C. in Mol Pharmacol (2009). 75(3) 534-41.
     
  • Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Mongillo, M.; McSorley, T.; Evellin, S.; Sood, A.; Lissandron, V.; Terrin, A.; Huston, E.; Hannawacker, A.; Lohse, M. J.; Pozzan, T.; Houslay, M. D.; Zaccolo, M. in Circ Res (2004). 95(1) 67-75.
     
  • Fluorescent sensors for rapid monitoring of intracellular cGMP. Nikolaev, V. O.; Gambaryan, S.; Lohse, M. J. in Nat Methods (2006). 3(1) 23-5.
     
  • FRET-based sensors for the human M(1)-, M(3)-, and M(5)-acetylcholine receptors. Ziegler, N.; Batz, J.; Zabel, U.; Lohse, M. J.; Hoffmann, C. in Bioorg Med Chem (2010).
     
  • G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Makino, A.; Prossnitz, E. R.; Bunemann, M.; Wang, J. M.; Yao, W.; Schmid-Schonbein, G. W. in Am J Physiol Cell Physiol (2006). 290(6) C1633-9.
     
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  • Gene expression profiling in susceptible interaction of grapevine with its fungal pathogen Eutypa lata: extending MapMan ontology for grapevine. Rotter, A.; Camps, C.; Lohse, M.; Kappel, C.; Pilati, S.; Hren, M.; Stitt, M.; Coutos-Thevenot, P.; Moser, C.; Usadel, B.; Delrot, S.; Gruden, K. in BMC Plant Biol (2009). 9 104.
     
  • GPCR and G proteins: drug efficacy and activation in live cells. Vilardaga, J. P.; Bunemann, M.; Feinstein, T. N.; Lambert, N.; Nikolaev, V. O.; Engelhardt, S.; Lohse, M. J.; Hoffmann, C. in Mol Endocrinol (2009). 23(5) 590-9.
     
  • Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form. Nigam, S.; Zafiriou, M. P.; Deva, R.; Kerstin, N.; Geilen, C.; Ciccoli, R.; Sczepanski, M.; Lohse, M. in FEBS Lett (2008). 582(2) 279-85.
     
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  • Hypoglycemia-dependent beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia unawareness in patients with Type-1 diabetes? Schwab, K. O.; Menche, U.; Schmeisl, G.; Lohse, M. J. in Horm Res (2004). 62(3) 137-41.
     
  • Identification of a C-terminal binding site for G-protein betagamma-subunits in phosducin-like protein. Schroder, S.; Bluml, K.; Dees, C.; Lohse, M. J. in FEBS Lett (1997). 401(2-3) 243-6.
     
  • Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. Raymond, J. R.; Fargin, A.; Lohse, M. J.; Regan, J. W.; Senogles, S. E.; Lefkowitz, R. J.; Caron, M. G. in Mol Pharmacol (1989). 36(1) 15-21.
     
  • Imaging cytoplasmic cAMP in mouse brainstem neurons. Mironov, S. L.; Skorova, E.; Taschenberger, G.; Hartelt, N.; Nikolaev, V. O.; Lohse, M. J.; Kugler, S. in BMC Neurosci (2009). 10 29.
     
  • Immunoadsorption in a 40 year old man with dilated cardiomyopathy and underlying active myocarditis. Muller, II; Klingel, K.; Nikolaev, V. O.; Jahns, R.; Gawaz, M. P.; Weig, H. J. in Clin Res Cardiol (2008). 97(10) 787-90.
     
  • Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues. Lupp, A.; Klenk, C.; Rocken, C.; Evert, M.; Mawrin, C.; Schulz, S. in Eur J Endocrinol (2010). 162(5) 979-86.
     
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  • Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a ligand-dependent fashion. Schlickum, S.; Sennefelder, H.; Friedrich, M.; Harms, G.; Lohse, M. J.; Kilshaw, P.; Schon, M. P. in Blood (2008). 112(3) 619-25.
     
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  • Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat. Puurunen, J.; Lohse, M. J.; Schwabe, U. in Naunyn Schmiedebergs Arch Pharmacol (1987). 336(5) 471-7.
     
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  • Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. Vilardaga, J. P.; Krasel, C.; Chauvin, S.; Bambino, T.; Lohse, M. J.; Nissenson, R. A. in J Biol Chem (2002). 277(10) 8121-9.
     
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  • Kinetics of heat shock protein 70 synthesis in the human heart after cold cardioplegic arrest. Schmitt, J. P.; Schunkert, H.; Birnbaum, D. E.; Aebert, H. in Eur J Cardiothorac Surg (2002). 22(3) 415-20.
     
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  • Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine A2A receptor. Michielan, L.; Bacilieri, M.; Schiesaro, A.; Bolcato, C.; Pastorin, G.; Spalluto, G.; Cacciari, B.; Klotz, K. N.; Kaseda, C.; Moro, S. in J Chem Inf Model (2008). 48(2) 350-63.
     
  • Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. Nikolaev, V. O.; Boettcher, C.; Dees, C.; Bunemann, M.; Lohse, M. J.; Zenk, M. H. in J Biol Chem (2007). 282(37) 27126-32.
     
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  • Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires the physical interaction of Gbetagamma with the channel. Michaelevski, I.; Chikvashvili, D.; Tsuk, S.; Fili, O.; Lohse, M. J.; Singer-Lahat, D.; Lotan, I. in J Biol Chem (2002). 277(38) 34909-17.
     
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  • Multicolor bimolecular fluorescence complementation reveals simultaneous formation of alternative CBL/CIPK complexes in planta. Waadt, R.; Schmidt, L. K.; Lohse, M.; Hashimoto, K.; Bock, R.; Kudla, J. in Plant J (2008). 56(3) 505-16.
     
  • Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. Sassi, Y.; Lipskaia, L.; Vandecasteele, G.; Nikolaev, V. O.; Hatem, S. N.; Aubart, F. Cohen; Russel, F. G.; Mougenot, N.; Vrignaud, C.; Lechat, P.; Lompre, A. M.; Hulot, J. S. in J Clin Invest (2008). 118(8) 2747-57.
     
  • N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. Volpini, R.; Costanzi, S.; Lambertucci, C.; Taffi, S.; Vittori, S.; Klotz, K. N.; Cristalli, G. in J Med Chem (2002). 45(15) 3271-9.
     
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  • Overexpressed A(1) adenosine receptors reduce activation of acetylcholine-sensitive K(+) current by native muscarinic M(2) receptors in rat atrial myocytes. Wellner-Kienitz, M. C.; Bender, K.; Meyer, T.; Bunemann, M.; Pott, L. in Circ Res (2000). 86(6) 643-8.
     
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  • Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor. Maack, C.; Bohm, M.; Vlaskin, L.; Dabew, E.; Lorenz, K.; Schafers, H. J.; Lohse, M. J.; Engelhardt, S. in Circulation (2003). 108(3) 348-53.
     
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  • Pertussis toxin does not inhibit the alpha 1-adrenoceptor-mediated effect on inositol phosphate production in the heart. Schmitz, W.; Scholz, H.; Scholz, J.; Steinfath, M.; Lohse, M.; Puurunen, J.; Schwabe, U. in Eur J Pharmacol (1987). 134(3) 377-8.
     
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  • Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Varani, K.; Gessi, S.; Merighi, S.; Vincenzi, F.; Cattabriga, E.; Benini, A.; Klotz, K. N.; Baraldi, P. G.; Tabrizi, M. A.; Lennan, S. M.; Leung, E.; Borea, P. A. in Biochem Pharmacol (2005). 70(11) 1601-12.
     
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  • Pharmacology of NO:cGMP signal transduction. Lohse, M. J.; Forstermann, U.; Schmidt, H. H. in Naunyn Schmiedebergs Arch Pharmacol (1998). 358(1) 111-2.
     
  • Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2. Ruiz-Gomez, A.; Humrich, J.; Murga, C.; Quitterer, U.; Lohse, M. J.; Mayor, Jr. in J Biol Chem (2000). 275(38) 29724-30.
     
  • Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo. Philipp, M.; Brede, M. E.; Hadamek, K.; Gessler, M.; Lohse, M. J.; Hein, L. in Nat Genet (2002). 31(3) 311-5.
     
  • Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins. Oey, M.; Lohse, M.; Scharff, L. B.; Kreikemeyer, B.; Bock, R. in Proc Natl Acad Sci U S A (2009). 106(16) 6579-84.
     
  • Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11. Zywietz, A.; Gohla, A.; Schmelz, M.; Schultz, G.; Offermanns, S. in J Biol Chem (2001). 276(6) 3840-5.
     
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  • Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6. Werthmann, R. C.; von Hayn, K.; Nikolaev, V. O.; Lohse, M. J.; Bunemann, M. in J Physiol (2009). 587(Pt 16) 4091-104.
     
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  • Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. Rochais, F.; Vilardaga, J. P.; Nikolaev, V. O.; Bunemann, M.; Lohse, M. J.; Engelhardt, S. in J Clin Invest (2007). 117(1) 229-35.
     
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  • Regulation of fusion activity by the cytoplasmic domain of a paramyxovirus F protein. Tong, S.; Li, M.; Vincent, A.; Compans, R. W.; Fritsch, E.; Beier, R.; Klenk, C.; Ohuchi, M.; Klenk, H. D. in Virology (2002). 301(2) 322-333.
     
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  • RNA interference of LIN5 in tomato confirms its role in controlling Brix content, uncovers the influence of sugars on the levels of fruit hormones, and demonstrates the importance of sucrose cleavage for normal fruit development and fertility. Zanor, M. I.; Osorio, S.; Nunes-Nesi, A.; Carrari, F.; Lohse, M.; Usadel, B.; Kuhn, C.; Bleiss, W.; Giavalisco, P.; Willmitzer, L.; Sulpice, R.; Zhou, Y. H.; Fernie, A. R. in Plant Physiol (2009). 150(3) 1204-18.
     
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  • Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. Nakagawa, Y.; Nagasawa, M.; Yamada, S.; Hara, A.; Mogami, H.; Nikolaev, V. O.; Lohse, M. J.; Shigemura, N.; Ninomiya, Y.; Kojima, I. in PLoS One (2009). 4(4) e5106.
     
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  • Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. Volpini, R.; Buccioni, M.; Ben, D. Dal; Lambertucci, C.; Lammi, C.; Marucci, G.; Ramadori, A. T.; Klotz, K. N.; Cristalli, G. in J Med Chem (2009). 52(23) 7897-900.
     
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  • Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as adenosine receptor antagonists. Pastorin, G.; Bolcato, C.; Cacciari, B.; Kachler, S.; Klotz, K. N.; Montopoli, C.; Moro, S.; Spalluto, G. in Farmaco (2005). 60(8) 643-51.
     
  • Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as potential adenosine receptor antagonists. Pastorin, G.; Bolcato, C.; Cacciari, B.; Kachler, S.; Klotz, K. N.; Montopoli, C.; Moro, S.; Spalluto, G. in Farmaco (2005). 60(4) 299-306.
     
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